Background & objectives: Malaria remains a significant public health challenge globally, with an estimated 249 million cases reported across 85 endemic countries and regions in 2022, reflecting an increase of 5 million cases from the previous year.Anopheles mosquitoes are the primary vectors responsible for transmitting malaria parasites to humans,
Novel investigations in retinoic-acid-induced cleft palate about the gut microbiome of pregnant mice
IntroductionCleft palate (CP) is one of the most common congenital birth defects in the craniofacial region, retinoic acid (RA) gavage is the most common method for inducing cleft palate model.Although several mechanisms have been proposed to illuminate RA-induced cleft palate during embryonic development, these findings are far from enough.Many ef
Extended Interneuronal Network of the Dentate Gyrus
Local interneurons control principal cells within individual brain areas, but anecdotal observations indicate that interneuronal axons sometimes extend beyond strict anatomical boundaries.Here, we use the case of the dentate Connection Hose gyrus (DG) to show that boundary-crossing interneurons with cell bodies in CA3 and CA1 constitute a numerical
Regulation of inflammation in diabetes: From genetics to epigenomics evidence
Background: Diabetes is one of the greatest public health challenges worldwide, and we still lack complementary approaches to significantly enhance the efficacy of preventive and therapeutic approaches.Genetic and environmental factors are the culprits involved in diabetes risk.Evidence from the last decade has highlighted that deregulation in the